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KMID : 1103720140700020111
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Journal of the Korean Society of Radiology
2014 Volume.70 No. 2 p.111 ~ p.118
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Radiofrequency Ablation of Hepatocellular Carcinoma Located in the Liver Dome Under Intermittent CT Fluoroscopy Guidance
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Park Dar-Lene
Cho Yun-Ku
Cho Hyun-Je
Kim Mi-Young
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Abstract
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Purpose: To evaluate the clinical effectiveness of an intermittent computed tomography (CT) fluoroscopy-guided radiofrequency (RF) ablation of hepatocellular carcinoma located in the liver dome.
Materials and Methods: Between 2005 and 2010 23 patients with hepatocellular carcinoma (HCC) nodules located in the liver dome underwent an intermittent CT fluoroscopy-guided RF ablation. The primary endpoint was the local tumor progression. Procedure-related complications occurred in 3 of 23 patients. To evaluate the prognostic factors for the local tumor progression, univariate and multivariate analyses were performed using the Cox proportional hazards model. The chi-squared test was performed to evaluate the association of access route and procedure-related complication. The study was approved by the Institutional Review Board of our hospital.
Results: The Tumor sizes ranged between 1.0 and 2.9 cm. An initial complete ablation was achieved in all patients. The median follow-up period was 31 months and the major complication rate was 4.3%. The cumulative rate of local tumor progression at 3 years was 20%. The univariate analysis revealed that only serum total bilirubin level (p = 0.048) and prior chemoembolization were statistically significant (p = 0.044), but there was no independently significant prognostic factor on multivariate analysis. Procedure-related complications occurred in 3 of 23 patients.
Conclusion: For HCC located in the liver dome an intermittent CT fluoroscopy-guided RF ablation could be performed safely and effectively.
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KEYWORD
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Hepatocellular Carcinoma, Radiofrequency Ablation, CT, Liver Dome, Local Recurrence
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